NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are painkillers commonly used to treat pain, fever, and inflammation. Prostaglandin analogs are simply mimickers of endogenous prostaglandins, which are hormone-like substances involved in numerous body functions including the dilation and constriction of blood vessels, control of blood pressure, modulation of inflammation, and the contraction and relaxation of smooth muscle. This pharmacology lecture covers topics such as the role of cyclooxygenases (COX-1 & COX-2) in inflammation, thromboxane, prostaglandins; mechanism of action, therapeutic uses and side effects of NSAIDs and various prostaglandin analogs. Drugs mentioned include; Selective COX-1 inhibitors; Ketorolac, Flurbiprofen, Ketoprofen, Indomethacin, low-dose Aspirin; Non-selective COX inhibitors; Naproxen, Ibuprofen, Piroxicam, Diflunisal; Selective COX-2 inhibitors; Meloxicam, Diclofenac, Celecoxib, Etodolac; Prostaglandin E1 analogs; Alprostadil, Lubiprostone, Misoprostol; Prostaglandin F2α analogs; Bimatoprost, Latanoprost, Travoprost; Prostacyclin analogs; Iloprost, and Treprostinil.
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